TABLE 2.

Proteomics/Metabolomics studies on PHPT.

Proteins/metabolites	Comparision	Biological process	References
Nucleophosmin, peroxiredoxin-2, Bcl-2-like protein-10, DNAJC2 protein (Hsp40), ATP synthase subunit day, aconitase 2, elongation factor Tu (p43), phosphatidylinositol transfer protein, MED26 protein (isoform-2), fibronectin type III, vacuole membrane protein 1 (HSPC292), prohibitin, nuclear receptor binding factor 2, zinc finger protein 394, Ras-related protein Rab-7b	Parathyroid adenomas vs. normal	Regulation of programed cell death cell organization and transcription, miscellaneous proteins, Ras protein signal transduction	Varshney et al., 2014
Nuclear receptor subfamily 2 group C member 2 (TR4), LIM domain only protein 3 (LMO3), calcium-binding protein B (S100B)	Oxyphilic cell vs. chief cell in parathyroid adenoma	p53 pathway	Lu et al., 2018
Ubiquinone oxidoreductase core subunit V1, cytochrome C oxidase subunit 7B, cytochrome C, ATP synthase, lin-7 homolog A, tenascin, etc.	Calcium-sensitive vs. calcium-resistant parathyroid tumors	Redox metabolism, GPCR trafficking, GPCR signal transduction, PI3 kinase signaling	Koh et al., 2018
Phosphorylcholine, choline, glycerophosphocholine, fumarate, succinate, lactate, glucose, glutamine, ascorbate, etc.	Single gland disease vs. multiglandular disease in PHPT	Tricarboxylic acid cycle	Battini et al., 2016
60 kDa heat shock protein, ubiquitin carboxyl-termial hydrolase, lamin-A/C, heterogeneous nuclear ribonucleo-proteins A2/B1, etc.	Parathyroid hyperplasia vs. adenoma	Energy metabolism, redox metabolism, protein folding etc.	Akpinar et al., 2017