TABLE 3.

Proteomics/Metabolomics studies on CKD-MBD.

Protein/metabolite	Comparision	Biological process	References
N-(1-Deoxy-1-fructosyl) tryptophan, N-acetylaspartylglutamic acid, glycylprolylhydroxyproline, (R)-pantothenic acid 4′-O-b-D-glucoside, aminohippuric acid, etc.	CKD-MBD vs. normal	Protein synthesis and amino acid metabolism, energy metabolism, and steroid hormone metabolism	Wu et al., 2015
Allyl isothiocyanate, L-phenylalanine, D-Aspartic acid, indoleacetaldehyde, and D-galactose corrected with PTH	SHPT vs. normal	Amino acid metabolism	Shen et al., 2019
Cullin-1, 5′-AMP-activiated protein kinase subunit beta-2, Carnitine palmitoyltransferase 1B, protein, E3 ubiquitin-protein ligase CBL, etc.	Oxyphil cell modules vs. Chief cell modules	Wnt signaling, TGF-β, ubiquitin mediated proteolysis, cell cycle regulation, protein synthesis	Li et al., 2018
Total 36 metabolites, especially ornithine	hyperphosphatemia- associated cardiovascular vs. normal	Urea cycle, arginine-, proline-, metabolism etc.	Zhou et al., 2016
IL-6, TNF-α,OPG,OPN,OCN,FGF-23, Fetuin-A	CKD stage vs. normal	RANK/RANKL/OPF signaling pathway, energy metabolism	Mihai et al., 2016
Vimentin, F-acting-capping protein subunit beta-alfa-1, WD repeat-containing protein 1, prelamin A/C, DnaJ homolog subfamily B member 11, 78kDa glucose-regulated protein, endoplasmin, stress-70 protein, protein disulfide-isomerase A, peroxiredoxin, etc.	High Turnover Bone disease vs. Low Turnover Bone Disease	Redox metabolism, protein biosynthesis degradation, transcription, energy and amino acid metabolism	Kasap et al., 2015