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. 2020 Sep 10;10:563666. doi: 10.3389/fonc.2020.563666

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Copyright © 2020 Sun, Xu, Jiang, Xu, Xu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment of H3K27 acetylation of SDHA was raised by chidamide in MM cells. MM cell line H929 treated by chidamide or DMSO for 24 h and then ChIP sequencing was performed. (A) Enrichment of mapped reads of ChIP sequencing. The peak of enrichment of H3K27 acetylation of cells treated by chidamide was much higher than cells treated by DMSO. (B) The heat map of CHIP sequencing signal enrichment reflects the enrichment of all genes in the upstream and downstream 3 kb of transcription starting sites. The signal enrichment of H3K27 acetylation sites in chidamide-treated H929 cells was significantly higher than that in the control H929 cells. (C) The signal enrichment of H3K27 acetylation sites of SDHA gene in chidamide-treated H929 cells was significantly higher than that in the control H929 cells.