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. 2020 Sep 10;10:563666. doi: 10.3389/fonc.2020.563666

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Copyright © 2020 Sun, Xu, Jiang, Xu, Xu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SDHA overexpression suppressed HIFα-ROS axis in MM cells. (A) Western blot showed that expression of HIFα in SDHA overexpression (OE) H929 cells was significantly lower than nc H929 cells. Chidamide decreased expression of HIFα in nc H929 cells. (B) Mitochondrial ROS production was determined by CM-H2DCFDA staining and flow cytometry. Production of ROS was decreased in SDHA overexpression (OE) H929 cells. Chidamide decreased the production of ROS.