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. 2020 Sep 10;10:563666. doi: 10.3389/fonc.2020.563666

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Copyright © 2020 Sun, Xu, Jiang, Xu, Xu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pattern diagram of chidamide-SDHA axis in MM cells. Transcription of SDHA was inhibited in MM cells. Expression of SDHA was obviously decreased which led TCA cycle to be blocked and then succinate accumulated. HIFA could not be degenerated which formed pseudo-hypoxia circumstance. Increased ROS raised oxidative stress in MM cells, which promoted proliferation and invasion of tumor. Chidamide acetylated H3K27 site of SDHA, and promoted expression of SDHA, in order to inhibit proliferation and invasion of MM cells.