FIGURE 3.

Fertility during female ageing. (a) Mean cumulative pup numbers for OoSirt1^ΔEx4/ΔEx4 and OoSirt1^+/+ females from 2 months to 12 months of age mated with young WT males. (b) Litter sizes of OoSirt1^ΔEx4/ΔEx4 and OoSirt1^+/+ females ≤7 months and >7 months. (c) Proportion of OoSirt1^ΔEx4/ΔEx4 and OoSirt1^+/+ females achieving live births (pregnancy rates) after mating with young WT males. Data are shown as mean ± SEM. Statistical analysis performed using two‐tailed Student's t test (b). p values are represented as *p ≤ 0.05, ns denotes p > 0.05. N, numbers of breeding pairs