FIGURE 1.

Bioinformatics analyses. (a) Overview of frequent gene co‐expression analysis in identifying novel Parkinson's disease‐associated genes. Eleven NCBI GEO DataSets were identified with the microarray datasets of the substantia nigra brain region of human PD patients. Seven genes were used as the anchor PD genes. See Section 4 for more details. (b) Ingenuity Pathway Analysis (IPA) revealed the connection of SMARCA4/Brm with MAPK kinase pathway. Red lines indicate genes known to interact with ERK signaling. Solid line: direct interaction; dash line: indirect interaction; arrows indicate the direction of interaction between two molecules. Different shapes indicate the type of the molecules