FIGURE 3.

Down‐regulation of Brahma in the dopaminergic neurons prevented shortening of life span in Drosophila PD models. (a, b) Perturbation of Brm activity did not significantly affect the life span of Drosophila in comparison to that of control flies (TH‐Gal4/+). Overexpression of a dsRNA construct or a constitutively activated allele of Brm was induced specifically in the DA neurons, respectively. The life span of both female and male flies was evaluated separately. (c, d) Down‐regulation of Brm partially restored the median life span in the female flies in α‐synuclein‐mediated PD model, while over‐activation of Brm did not have an aggravating effect. Note that the life span of male flies with α‐synuclein overexpression was relatively normal. (e, f) Down‐regulation of Brm suppressed the shortening of the median life span of both female and male flies in LRRK2‐mediated PD model; in contrast, over‐activation of Brm did not have discernible impacts