Table 3.
Top 30 most significant SOMAmer reagent targets associated negatively (decreased expression) with frailty phenotype
| SeqId | SomaId | UniProt | Target | Target full name | Estimate | Std Error | p_value |
|---|---|---|---|---|---|---|---|
| 15559‐5 | SL011048 | P58335 | ANTR2 | Anthrax toxin receptor 2 | −0.0938 | 0.0100 | 7.95E−20 |
| 2677‐1 | SL002644 | P00533 | ERBB1 | Epidermal growth factor receptor | −0.1611 | 0.0198 | 1.38E−15 |
| 6544‐33 | SL012542 | Q92832 | NELL1 | Protein kinase C‐binding protein NELL1 | −0.0547 | 0.0067 | 1.66E−15 |
| 10521‐10 | SL017989 | Q9BRK3 | MXRA8 | Matrix‐remodeling‐associated protein 8 | −0.1061 | 0.0133 | 4.80E−15 |
| 8885‐6 | SL018710 | Q8IZS8 | CA2D3 | Voltage‐dependent calcium channel subunit alpha‐2/delta‐3 | −0.0908 | 0.0114 | 6.09E−15 |
| 9769‐48 | SL008968 | Q8NFT8 | DNER | Delta and Notch‐like epidermal growth factor‐related receptor | −0.0891 | 0.0113 | 1.23E−14 |
| 12549‐33 | SL014636 | O60760 | PTGD2 | Hematopoietic prostaglandin D synthase | −0.0798 | 0.0108 | 3.21E−13 |
| 4498‐62 | SL003764 | P13591 | NCAM‐120 | Neural cell adhesion molecule 1, 120 kDa isoform | −0.1106 | 0.0151 | 4.89E−13 |
| 15573‐110 | SL008782 | O14594 | CSPG3 | Neurocan core protein | −0.0667 | 0.0092 | 8.88E−13 |
| 2765‐4 | SL021043 | O95390 O14793 | GDF‐11/8 | Growth/differentiation factor 11/8 | −0.0967 | 0.0134 | 1.08E−12 |
| 2974‐61 | SL004855 | Q12860 | contactin‐1 | Contactin‐1 | −0.1100 | 0.0153 | 1.45E−12 |
| 5843‐60 | SL003542 | Q96KQ7 | NG36 | Histone‐lysine N‐methyltransferase EHMT2 | −0.0534 | 0.0076 | 3.66E−12 |
| 7933‐75 | SL018350 | Q9P0K1 | ADA22 | Disintegrin and metalloproteinase domain‐containing protein 22 | −0.0838 | 0.0119 | 4.30E−12 |
| 6556‐5 | SL012863 | Q9UJA9 | ENPP5 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 | −0.0713 | 0.0102 | 6.83E−12 |
| 18896‐23 | SL021212 | Q8IZP7 | H6ST3 | Heparan‐sulfate 6‐O‐sulfotransferase 3 | −0.1397 | 0.0201 | 7.92E−12 |
| 12630‐8 | SL019787 | P53365 | ARFP2 | Arfaptin‐2 | −0.0706 | 0.0103 | 1.16E−11 |
| 10464‐6 | SL008696 | Q9H6X2 | ANTR1 | Anthrax toxin receptor 1 | −0.0788 | 0.0117 | 2.87E−11 |
| 12727‐7 | SL019877 | Q9P2B2 | FPRP | Prostaglandin F2 receptor negative regulator | −0.0881 | 0.0132 | 4.24E−11 |
| 8900‐28 | SL007582 | Q92859 | NEO1 | Neogenin | −0.1184 | 0.0184 | 2.17E−10 |
| 5698‐60 | SL005005 | P22105 | Tenascin‐X | Tenascin‐X | −0.0916 | 0.0146 | 6.15E−10 |
| 4187‐49 | SL000247 | P52209 | 6‐Phosphogluconate dehydrogenase | 6‐phosphogluconate dehydrogenase, decarboxylating | −0.0304 | 0.0049 | 1.12E−09 |
| 3235‐50 | SL010391 | Q8TEU8 | WFKN2 | WAP, Kazal, immunoglobulin, Kunitz and NTR domain‐containing protein 2 | −0.0656 | 0.0108 | 1.60E−09 |
| 7210‐25 | SL004470 | P51693 | Amyloid‐like protein 1 | Amyloid‐like protein 1 | −0.0450 | 0.0074 | 1.73E−09 |
| 8841‐65 | SL008847 | Q8IUL8 | CILP2 | Cartilage intermediate layer protein 2 | −0.0651 | 0.0107 | 2.13E−09 |
| 6388‐21 | SL017451 | Q96EE4 | CC126 | Coiled‐coil domain‐containing protein 126 | −0.0706 | 0.0118 | 3.22E−09 |
| 15491‐20 | SL008437 | Q9HCU0 | CD248 | Endosialin | −0.0775 | 0.0131 | 4.72E−09 |
| 10833‐64 | SL012788 | Q96QV1 | HHIP | Hedgehog‐interacting protein | −0.1040 | 0.0176 | 4.97E−09 |
| 8039‐41 | SL018368 | Q8N128 | F177A | Protein FAM177A1 | −0.0783 | 0.0133 | 5.92E−09 |
| 6440‐31 | SL012493 | Q13361 | MFAP5 | Microfibrillar‐associated protein 5 | −0.0763 | 0.0130 | 6.58E−09 |
| 10565‐19 | SL017951 | O94933 | SLIK3 | SLIT and NTRK‐like protein 3 | −0.0323 | 0.0055 | 7.64E−09 |