Fig. 2.

Risk of treatment failure for use of antipsychotics compared with non-use of antipsychotics after clozapine discontinuation, within-individual model.

In bold are depicted the agents that are significant after Bonferroni correction (P < 0.003125). Hazard ratios are adjusted for the sequential order of treatments, concomitant use of other psychotropic drugs and time since cohort entry (i.e. the moment of clozapine discontinuation). Antipsychotic polypharmacy refers to the use of two or more antipsychotics concomitantly. LAI, long-acting injectable antipsychotic.