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. 2020 Sep 23;10:15524. doi: 10.1038/s41598-020-72660-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The macroscale results of hypoxia optimization. The results obtained in tests on changes in mitochondrial membrane potential for (A) H9C2 and (B) HCM cell lines. (C) H9C2 cells and (D) HCM cells after 120 min incubation with FCCP. Both cell lines were stained with JC-1. The results obtained in tests on changes in concentration of intracellular calcium ions for (E) H9C2 and (F) HCM cell lines. N ≥ 3, asterisks indicate p < 0.05.