Figure 1.

Genomic screening of response marker for HER2-positive breast cancers. Mutations and copy number alterations were analyzed and profiled in the screening set, including 15 samples with pCR and 18 samples with non-pCR. The vertical line shows the name of the genes, and ordered by frequency of alteration. When a sample had a mutation in one gene, the box is colored in black. When a sample had a gain and loss in one gene, the box is colored in orange and green, respectively. ERBB2 (HER2) gain was associated with pCR. ER-negative status was also associated with pCR, which was in line with previous reports^36,37.