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. 2020 Sep 23;10:15479. doi: 10.1038/s41598-020-72484-8

Figure 1.

Figure 1

Models of the autoinducer AI-1, AI-2 and AI-3 quorum sensing system of A. hydrophila. (a) Schematic representation of QS regulation by AhyI/AhyR in A. hydrophila. AhyR* represents the active AhyR. (b) Synthesis of AHL catalysed by AhyI protein using acyl-ACP and SAM. Fas II represents type II fatty acid synthesis reactions. (c) A putative regulatory mechanism of the LuxS-type 2 QS system in A. hydrophila. (d) AI-2 synthetic routes based on LuxS protein. DPD undergoes further reactions to form distinct biologically active signal molecules (AI-2), including (2S,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuryl borate (S-THMF-borate) and (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran (R-THMF). (e) A putative regulatory mechanism of the QseBC-based AI-3 system in A. hydrophila. The “P” surrounded by a circle represents phosphorylation.