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. 2020 Sep 14;2020:4616308. doi: 10.1155/2020/4616308

Figure 2.

Figure 2

MCM increases the expression of proinflammatory mediators in leptomeningeal cells, which is suppressed by AG490. (a, b) TNF-α mRNA and protein levels in leptomeningeal cells after 12 h of treatment were measured by RT-qPCR and ELISA; (c, d) IL-6 mRNA and protein levels in leptomeningeal cells after 12 h of treatment were measured by RT-qPCR and ELISA; (e, f) IL-1β mRNA and protein levels in leptomeningeal cells after 12 h of treatment were measured by RT-qPCR and ELISA. Each column and bar represent the mean ± SEM (n = 3, each). Asterisks indicate a statistically significantly difference from the value in corresponding group (∗∗P<0.01; ∗∗∗P < 0.001).