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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Glia. 2020 Jul 8;68(10):2148–2166. doi: 10.1002/glia.23883

FIGURE 3.

FIGURE 3

Driver mutation creates unique immune microenvironments in different subtypes of mGBM. (a) t-SNE plot of the NanoString PanCancer Immune Profiling data. (b) Immune pathway function in PDGFB-overexpressing, Nf1-silenced, and EGFRvIII-expressing tumors. (c) Unsupervised hierarchical analysis of NanoString PanCancer Immune Profiling data. (d) Gene Ontology analysis of differentially enriched genes in the three mGBM subtypes. (e) IHC micrographs of IBA1 immunostaining in murine and human GBM subtypes. (f) IHC micrographs of CD31 immunostaining in murine and human GBM subtypes *p < .05, **p < .01, ***p < .001, ****p < .0001, by one-way ANOVA with Tukey’s posthoc test