TABLE 3.

Strengths and limitations of WGS versus targeted sequencing via next-generation sequencing

Whole-genome sequencing	Targeted sequencing
Strengths	Strengths
Full genome sequenced	Sequence directly from sample
No prespecified targets needed	Large number of gene targets
Comprehensive solution	Less expensive than WGS
Detect rare mutations and heteroresistance	Simpler bioinformatics and storage
	Detect rare mutations and heteroresistance
Weaknesses	Weaknesses
Requires culture isolates	Knowledge of targets required
Slower than targeted NGS	Less information than WGS
Complicated bioinformatics	Expensive
Expensive