. Author manuscript; available in PMC: 2020 Sep 24.

Published in final edited form as: JAMA Surg. 2018 Apr 1;153(4):299–300. doi: 10.1001/jamasurg.2017.5080

Table.

Examples of Ancestry Associated With Cancer Risk

Ancestral Component (Characterization Mechanism)	Cancer Risk
Ashkenazi (Eastern/Central European) Jewish heritage¹ (self-reported)	Increased risk of BRCA 1 and BRCA 2 mutations
Afro-Caribbean heritage² (self-reported)	Increased risk of BRCA 1 and BRCA 2mutations
Variable extents of Native American ancestry in mixed-heritage Hispanic/Latina women³ (ancestry informative marker genotyping)	Reduced risk of breast cancer associated with greater extent of Native American ancestry
Variable extents of Native American ancestry in mixed-heritage children with admixed heritage⁴ (ancestry informative marker genotyping)	Higher rates of relapse in children with acute lymphoblastic leukemia associated with greater extent of Native American ancestry
African ancestry in African American women with mixed heritage⁵ (ancestry informative marker genotyping)	Novel estrogen receptor–negative breast cancer susceptibility locus