Table 3.

Immediate (level) and relative (slope) changes in adherence following the introduction of the adherence guidelines

	IRR	95% confidence interval		p value
Period (level change at Dec 2018)	1.421	1.080	1.869	0.012
Month (slope prior to Dec 2018)	1.053	0.969	1.144	0.225
Month X period (additional increase in slope for month after Dec 2018)	0.999	0.917	1.090	0.990

Using a multilevel Poisson regression model with fixed effects for month, period (before versus after Dec 2018) and a month X period interaction. A random intercept was included for the participant

IRR incidence rate ratio from Poisson regression model