Table 1. Cytotoxicity Data of Compounds 1–10 against Five Cell Lines.
| IC50 (μM)a |
|||||
|---|---|---|---|---|---|
| compound | PC3 | SKOV3 | A549 | MCF-7 | HEp-2 |
| 1 | 15.4 ± 1.3 | ≥100 | ≥100 | 13.5 ± 3.5 | 56.3 ± 3.2 |
| 2 | 4.2 ± 1.3 | 32.5 ± 7.4 | 28.3 ± 0.9 | 6.1 ± 1.8 | 20.9 ± 6.2 |
| 3 | 15.2 ± 1.0 | 46.0 ± 6.8 | 52.3 ± 8.0 | 30.0 ± 7.4 | 54.9 ± 3.0 |
| 4 | 3.9 ± 1.2 | 33.8 ± 6.0 | 37.9 ± 7.5 | 12.8 ± 3.3 | 26.4 ± 6.5 |
| 5 | 12.6 ± 4.0 | 31.8 ± 4.6 | 25.9 ± 1.0 | 16.3 ± 3.4 | 25.0 ± 7.1 |
| 6 | 17.4 ± 2.3 | 68.6 ± 2.2 | 61.2 ± 3.3 | 28.9 ± 1.2 | 26.8 ± 1.1 |
| 7 | 8.1 ± 0.3 | 29.4 ± 2.9 | 29.3 ± 7.9 | 5.8 ± 0.1 | 27.6 ± 3.4 |
| 8 | 3.9 ± 0.6 | 36.9 ± 2.5 | 44.8 ± 6.1 | 8.3 ± 0.9 | 22.7 ± 0.3 |
| 9 | 4.7 ± 0.9 | 50.2 ± 6.5 | 45.6 ± 3.6 | 14.6 ± 5.0 | 25.6 ± 1.2 |
| 10 | 4.3 ± 0.8 | 20.2 ± 5.0 | 17.8 ± 3.8 | 6.1 ± 0.3 | 12.6 ± 2.7 |
| docetaxel | 0.6 ± 0.2 | 0.3 ± 0.3 | 1.0 ± 0.4 | 1.4 ± 0.2 | 0.2 ± 0.0 |
a
The results are IC50 values of compounds against each cancer cell line: PC3 (prostate), SKOV3 (ovarian), A549 (lung), MCF-7 (breast), and HEp-2 (laryngeal); docetaxel was used as a positive control.