Table 10. Comparison of the Activity of Pd-C3 with Previously Published Data in the Carbonylative Sonogashira Coupling Reactions of Aryl Iodides and Alkynes.
| ref | catalyst | co-catalyst/ligand/additive | base | time (h) | yield (%) |
|---|---|---|---|---|---|
| (18) | PdCl2 (6 mol %) | PPh3 (12 mol %) | Et3N | 24 | 46–95 |
| (26) | Pd@MOF (1 mol %) | Et3N | 12 | 62–98 | |
| (50) | Pd-NHC-Py (0.1 mol %) | Et3N | 6 | 88–94 | |
| (65) | Pd(OAc)2 (2 mol %) | tri(2-furyl)- phosphine (4 mol %) | DIPEA | 20 | 62–98 |
| (66) | MCM-41-Pd-PPh2 (4 mol %) | Et3N | 36–72 | 45–91 | |
| (67) | Pd(OAc)2 (3 mol %) | I2 (1.3 mol %) PPh3 (1.3 mol %) | Et3N | 4 | 44–88 |
| this work | Pd-NHC-Py (Pd-C3) (0.03 mol %) | Et3N | 3–18 | 67–98 |