Table 3:

Orofacial clefts and chromosomal anomalies

Chromosomal anomaly	Aetiology	Present congenital heart diseases associations
Velocardiofacialsyndrome55/DiGeorge syndrome56 or Chromosome 22q11.2 deletion syndrome56	Genetic-autosomal dominant. Deletion in Chromosome 22q11	Interrupted aortic arch type B, truncus arteriosus,tetralogy of Fallot, pulmonary atresia with ventricular septal defect, pulmonary atresia with a ventricular septal defect
Edward syndrome57	Sporadic, Trisomy 18	Ventricular septal defect, Patent ductus arteriosus, transposition of great arteries, pulmonary atresia
Patau syndrome58	Sporadic, Trisomy 13	Ventricular septal defect, atrial septal defect, Patent ductus arteriosus