Table 3. Calculated ADME parameters of compounds 6a–6i.
| Comp. | MW | RB | DM | MV | DHB | AHB | PSA | log P | log S | PCaco | log BB | PMDCK | PM | % HOA | VRF | VRT |
| 6a | 447.501 | 9 | 5.539 | 1305.5 | 1 | 6.5 | 111.04 | 4.117 | –6.094 | 165.361 | –1.729 | 246.297 | 4 | 90.757 | 0 | 1 |
| 6b | 477.527 | 11 | 6.217 | 1398 | 1 | 8.2 | 120.47 | 4.173 | –6.138 | 228.846 | –1.708 | 498.468 | 5 | 93.612 | 0 | 1 |
| 6c | 461.528 | 10 | 13.286 | 1360.3 | 1 | 6.5 | 114.67 | 4.427 | –6.62 | 126.056 | –1.952 | 234.915 | 4 | 90.464 | 0 | 1 |
| 6d | 461.528 | 9 | 9.849 | 1328.1 | 1 | 6.5 | 111.46 | 4.242 | –6.164 | 151.441 | –1.716 | 249.063 | 4 | 90.808 | 0 | 1 |
| 6e | 459.512 | 10 | 4.477 | 1271.5 | 1 | 6.5 | 116.46 | 4.004 | –4.364 | 209.254 | –1.287 | 326.433 | 5 | 91.927 | 0 | 0 |
| 6f | 475.555 | 11 | 7.351 | 1420.4 | 1 | 6.5 | 113.6 | 5.072 | –7.157 | 232.388 | –1.734 | 542.708 | 4 | 86.033 | 1 | 1 |
| 6g | 475.555 | 10 | 14.484 | 1363.6 | 1 | 6.5 | 112.64 | 4.395 | –6.126 | 175.686 | –1.782 | 203.019 | 4 | 92.855 | 0 | 1 |
| 6h | 495.545 | 9 | 13.006 | 1430.2 | 1 | 6.5 | 118.05 | 5.065 | –7.392 | 119.309 | –1.998 | 199.191 | 5 | 80.813 | 1 | 1 |
| 6i | 509.572 | 9 | 8.779 | 1468.8 | 1 | 6.5 | 107.28 | 5.526 | –7.687 | 259.671 | –1.566 | 529.221 | 5 | 76.599 | 2 | 1 |