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. 2020 Sep 23;10(9):e041983. doi: 10.1136/bmjopen-2020-041983

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Spline plot demonstrating marked non-linearity in relationship between age and outcome after adjustment for other factors included in the final model.