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PCOS Symptoms. Physical signs of PCOS include obesity (disproportionately central), acne, hirsutism, acanthosis nigricans (hyperpigmentation in the skin folds which is a manifestation of insulin resistance). PCOS is also associated with irregular periods and increased risk of diabetes, cardiovascular disease and infertility. Multiple follicular cysts may be seen on ovarian ultrasound in PCOS.
