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. 2020 Sep 23;12:114. doi: 10.1186/s13195-020-00685-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Voxel-wise maps for Aβ-positive AD dementia-specific PCs of tau PET and group-wise averaged tau PET images for each quartile of PC scores in 114 Aβ-positive individuals. Individual PC1 scores correlated with the tau uptake in the entire cortex and there was an increasing trend of cortical tau burden with the advancement of the PC1 quartile groups. Individual PC2 scores correlated with the tau uptake in the prefrontal, parietal, occipital, and posterior cingulate cortices. The lowest PC2 quartile group (Q1) showed a temporal predominance pattern while the highest PC2 quartile group (Q4) showed a parietal predominance pattern. Significance maps for the voxel-wise correlation analysis between the individual scores for the PCs and tau uptake are overlaid on the template. Only the voxels that survived after correcting for multiple comparisons with family-wise error (P < 0.05) are displayed. Color bars represent PCs (bidirectional cold and hot colors), −Log₁₀P (rainbow color) and SUVR (rainbow color). PC, principal component; AD, Alzheimer’s disease; SUVR, standardized uptake value ratio; Qn, quartiles