Table 4.
Association Between Frailty and Symptoms Frequently Experienced
| SE | Unadjusted P Value | Odds Ratio | 95% CI | |
|---|---|---|---|---|
| Itching | ||||
| - Frailty | 0.31 | < 0.001* | 3.17 | 1.72–5.84 |
| - Age | 0.02 | 0.89 | 1.00 | 0.97–1.03 |
| - Female | 0.28 | 0.04 | 0.56 | 0.32–0.97 |
| - eGFR | 0.01 | 0.48 | 0.99 | 0.97–1.02 |
| - Haemoglobin | 0.01 | 0.37 | 0.99 | 0.98–1.01 |
| Sleep disturbance | ||||
| - Frailty | 0.29 | < 0.001* | 2.97 | 1.68–5.25 |
| - Age | 0.01 | 0.61 | 0.99 | 0.97–1.02 |
| - Female | 0.27 | 0.002* | 2.34 | 1.38–3.96 |
| - eGFR | 0.01 | 0.37 | 0.99 | 0.96–1.02 |
| - Haemoglobin | 0.01 | 0.05 | 1.02 | 1.00–1.04 |
| Loss of appetite | ||||
| - Frailty | 0.79 | 0.07 | 4.34 | 0.91–20.70 |
| - Age | 0.03 | 0.34 | 1.03 | 0.97–1.08 |
| - Female | 0.48 | 0.14 | 2.04 | 0.80–5.17 |
| - eGFR | 0.02 | 0.05 | 0.96 | 0.92–1.00 |
| - Haemoglobin | 0.01 | 0.17 | 0.98 | 0.96–1.01 |
| Tiredness | ||||
| - Frailty | 0.28 | < 0.001* | 3.90 | 2.25–6.78 |
| - Age | 0.01 | 0.02 | 0.97 | 0.94–0.99 |
| - Female | 0.26 | 0.01 | 1.97 | 1.17–3.30 |
| - eGFR | 0.01 | 0.07 | 0.98 | 0.95–1.00 |
| - Haemoglobin | 0.01 | 0.81 | 1.00 | 0.98–1.01 |
| Bone/joint pain | ||||
| - Frailty | 0.26 | < 0.001* | 3.56 | 2.14–5.92 |
| - Age | 0.01 | 0.29 | 1.02 | 0.99–1.04 |
| - Female | 0.26 | 0.007* | 2.03 | 1.21–3.40 |
| - eGFR | 0.01 | 0.06 | 0.98 | 0.95–1.00 |
| - Haemoglobin | 0.01 | 0.72 | 1.00 | 0.98–1.01 |
| Poor concentration | ||||
| - Frailty | 0.41 | 0.001* | 3.94 | 1.75–8.87 |
| - Age | 0.02 | 0.66 | 1.01 | 0.97–1.04 |
| - Female | 0.33 | 0.06 | 1.87 | 0.98–3.56 |
| - eGFR | 0.02 | 0.48 | 0.99 | 0.96–1.02 |
| - Haemoglobin | 0.01 | 0.25 | 1.01 | 0.99–1.04 |
| Loss of muscle strength | ||||
| - Frailty | 0.32 | < 0.001* | 4.94 | 2.61–9.35 |
| - Age | 0.02 | 0.02 | 1.04 | 1.01–1.07 |
| - Female | 0.29 | 0.23 | 1.42 | 0.80–2.51 |
| - eGFR | 0.02 | 0.04 | 0.97 | 0.94–1.00 |
| - Haemoglobin | 0.01 | 0.57 | 1.01 | 0.99–1.02 |
| Breathlessness | ||||
| - Frailty | 0.40 | < 0.001* | 5.65 | 2.56–12.48 |
| - Age | 0.02 | 0.29 | 1.02 | 0.98–1.05 |
| - Female | 0.29 | 0.27 | 1.38 | 0.78–2.43 |
| - eGFR | 0.01 | 0.68 | 0.99 | 0.97–1.02 |
| - Haemoglobin | 0.01 | 0.06 | 0.99 | 0.97–1.00 |
| Cramp/muscle stiffness | ||||
| - Frailty | 0.34 | < 0.001* | 4.25 | 2.19–8.24 |
| - Age | 0.02 | 0.86 | 1.00 | 0.97–1.03 |
| - Female | 0.29 | 0.03 | 1.90 | 1.07–3.37 |
| - eGFR | 0.02 | 0.26 | 0.98 | 0.96–1.01 |
| - Haemoglobin | 0.01 | 0.08 | 1.02 | 1.00–1.04 |
| Restless legs | ||||
| - Frailty | 0.35 | 0.03 | 2.10 | 1.06–4.17 |
| - Age | 0.02 | 0.59 | 1.01 | 0.98–1.04 |
| - Female | 0.31 | 0.91 | 1.04 | 0.57–1.89 |
| - eGFR | 0.02 | 0.78 | 1.00 | 0.97–1.04 |
| - Haemoglobin | 0.01 | 0.86 | 1.00 | 0.98–1.02 |
| Feeling cold | ||||
| - Frailty | 0.29 | 0.002* | 2.45 | 1.39–4.31 |
| - Age | 0.01 | 0.59 | 1.01 | 0.98–1.03 |
| - Female | 0.25 | 0.15 | 1.45 | 0.88–2.38 |
| - eGFR | 0.01 | 0.20 | 0.98 | 0.96–1.01 |
| - Haemoglobin | 0.01 | 0.91 | 1.00 | 0.98–1.02 |
| Urinary frequency | ||||
| - Frailty | 0.29 | 0.13 | 1.54 | 0.88–2.71 |
| - Age | 0.01 | 0.05 | 1.03 | 1.00–1.06 |
| - Female | 0.26 | 0.58 | 1.15 | 0.70–1.91 |
| - eGFR | 0.01 | 0.44 | 0.99 | 0.96–1.02 |
| - Haemoglobin | 0.01 | 0.30 | 1.01 | 0.99–1.02 |
*Remain statistically significant following Bonferroni correction