Table 3:
Frequency of individual hot-spot mutations detected by BEAMing of plasma DNA in the CORRECT trial
| Frequency in COSMIC*35 | Plasma DNA BEAMing in CORRECT | |
|---|---|---|
| KRAS | ||
| G12D | 5783/16 453 (35%) | 116/413 (28%) |
| G12V | 3677/16 453 (22%) | 72/413 (17%) |
| G12C | 1334/16 453 (8%) | 35/413 (8%) |
| G12A | 1039/16 453 (6%) | 36/413 (9%) |
| G12S | 963/16 453 (6%) | 16/413 (4%) |
| G12R | 203/16 453 (1%) | 9/413 (2%) |
| G13D | 3235/16 453 (20%) | 67/413 (16%) |
| Q61H | 126/16 453 (1%) | 50/413 (12%) |
| A146T | 93/16 453 (1%) | 12/413 (3%) |
| PIK3CA | ||
| E542K | 273/1098 (25%) | 27/89 (30%) |
| E545K | 412/1098 (38%) | 37/89 (42%) |
| E545G | 36/1098 (3%) | 9/89 (10%) |
| H1047R | 306/1098 (28%) | 12/89 (13%) |
| H1047L | 47/1098 (4%) | 3/89 (3%) |
| H1047Y | 24/1098 (2%) | 1/89 (1%) |
In total, we identified 413 KRAS mutations and 89 PIK3CA mutations. BRAF is not shown because only a single mutation (V600E) was assessed for this gene. COSMIC=Catalogue of Somatic Mutations in Cancer.
*
Colorectal cancer mutation data obtained from the COSMIC database; frequency data are included only for hot-spot mutations assessed in our study.