TABLE 3.
Summary of multivariable logistic regression models predicting amyloid status (positive vs negative) in a sample including all impairment levels
| Model 1 (demographics) (n = 634) | Model 2 (self‐reported health information) (n = 634) | Model 3 (demographics + self‐reported health information) (n = 634) | |
|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Characteristics | |||
| Age | 1.03 (1.00, 1.06) | 1.03 (0.99, 1.06) | |
| Female sex | 0.72 (0.52, 0.99) | 0.75 (0.53, 1.05) | |
| Education in years (6–20) | 0.95 (0.89, 1.01) | 0.94 (0.88, 1.00) | |
| Family history of AD | 1.67 (1.17, 2.38) a | 1.73 (1.21, 2.48) a | |
| Self‐reported memory concern | 1.39 (0.77, 2.52) | 1.44 (0.79, 2.64) | |
| Geriatric Depression Scale‐Short Form score | 0.90 (0.85 0.97) a | 0.90 (0.84, 0.97) a | |
| Self‐reported Everyday Cognition Scale score | 0.89 (0.66, 1.22) | 0.89 (0.66, 1.22) | |
| Self‐reported cognitive impairment | 2.99 (1.98, 4.53) b | 2.84 (1.88, 4.32) b | |
| AUC (cAUC) | 0.57 | 0.67 | 0.68 (0.66) |
| Sensitivity | 76.23% | 78.55% | 76.23% |
| Specificity | 30.10% | 45.33% | 48.79% |
| PPV | 56.56% | 63.17% | 63.99% |
| NPV | 51.48% | 63.90% | 63.23% |
Abbreviations: AD, Alzheimer's disease; AUC, area under the curve; cAUC, cross‐validated area under the curve; CI, confidence interval; MCI, mild cognitive impairment; NPV, negative predictive value; OR, odds ratio; PPV, positive predictive value.
a
= P‐values < .05.
b
= P‐values < .001.