TABLE 4.
Summary of multivariable logistic regression models predicting amyloid status (positive vs negative) in CU and MCI
| Model 1 (demographics) (n = 533) | Model 2 (self‐reported health information) (n = 533) | Model 3 (demographics + self‐reported health information) (n = 533) | |
|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Characteristics | |||
| Age | 1.03 (0.99, 1.06) | 1.03 (0.99,1.06) | |
| Female sex | 0.69 (0.48, 0.98) b | 0.71 (0.49, 1.02) | |
| Education in years (6–20) | 0.96 (0.89, 1.02) | 0.96 (0.89, 1.03) | |
| Family history of AD | 1.64 (1.13, 240) b | 1.72 (1.17,2.52) b | |
| Self‐reported memory concern | 1.40 (0.75, 2.61) | 1.41 (0.76, 2.65) | |
| Geriatric Depression Scale‐Short Form score | 0.93 (0.87, 0.99) b | 0.93 (0.87, 1.00) | |
| Self‐reported Everyday Cognition Scale score | 0.885 (0. 63, 1.25) | 0.88 (0.62,1.25) | |
| Self‐reported cognitive impairment | 2.33 (1.51, 3.60) b | 2.21 (1.42, 3.42) b | |
| AUC (cAUC) | 0.57 | 0.64 | 0.65 (0.62) |
| Sensitivity | 55.09% | 65.66% | 65.28% |
| Specificity | 57.46% | 51.12% | 57.46% |
| PPV | 56.15% | 57.05% | 60.28% |
| NPV | 56.41% | 60.09% | 62.60% |
Abbreviations: AD, Alzheimer's disease; AUC, area under the curve; cAUC, cross‐validated area under the curve; CI, confidence interval; MCI, mild cognitive impairment; NPV, negative predictive value; OR, odds ratio; PPV, positive predictive value
a
= P‐values = < .05.
b
= P‐values < .001.