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. 2020 Sep 23;5(5):e000872. doi: 10.1136/esmoopen-2020-000872

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© Author (s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, any changes made are indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Reported markers, actionability and number of treatment suggestions. (A–C) Stacked bar charts from NAVIFY (A: top), QCI (B: centre) and CureMatch (C: bottom) per patient and per tumour entity (left, BC; centre, CRC; right, NSCLC). Reported markers (orange) represent all alterations reported to the clinical decision support tool, whereas actionable targets (turquoise) are those alterations which were successfully matched to a therapy. Matching drugs (dark blue) correspond to the total number of drugs identified for each patient's molecular profile. In the CureMatch analysis, the actionable targets in the BC and NSCLC samples could be categorised as either a genome (light blue) or protein variant (red). BC, breast cancer; CRC, colorectal cancer; NSCLC, non-small-cell lung cancer.QCI, QIAGEN Clinical Insight.