FIGURE 1.

Hsp90α residues are rank‐ordered by their frequency of forming direct hydrogen‐bonds (a) and water‐bridged hydrogen bonds (b) to inhibitors. Data compiled from Table S1. The contacts on Hsp90α are listed as the single letter amino acid code, the residue number in the PDB and the name of specific atom contacted by IUPAC‐IUB rules. ²⁵ (c) Key residues involved in hydrogen bonding to radicicol (PDB: 4EGK), EC144 (PDB: 3NMQ), AUY922 (PDB: 2VCI), and ADP (PDB: 6GQ6). Direct hydrogen bonds are dark blue and water‐mediated bonds are light blue