Table 2.

Molecular docking results of FDA drugs with the wild type SARS-CoV-2 helicase.

Drug name	Glide energy	Glide emodel	XP GScore	XP HBond	XP Lipophilic EvdW	XP Electro	MMGBSA dG Bind
Cangrelor	−64.566	−88.135	−11.478	−3.016	−2.762	−1.454	−47.46
Pemetrexed	−56.766	−75.064	−10.192	−2.887	−1.992	−1.117	−38.65
Fludarabine	−48.921	−57.730	−9.769	−3.850	−1.288	−1.736	−19.86
Folic acid	−58.839	−87.011	−9.424	−3.012	−2.014	−1.439	−32.18
Cidofovir	−42.543	−52.251	−9.204	−3.884	−1.187	−1.637	−18.76
Zanamivir	−34.220	−49.983	−9.186	−6.762	−0.791	−1.617	−25.45
Polydatin	−53.163	−69.046	−7.276	−2.843	−3.182	−1.326	−44.52
Sapropterin	−33.493	−43.767	−6.904	−4.104	−1.357	−1.199	−23.80
Ertapenem	−51.556	−68.522	−6.782	−2.810	−2.294	−1.185	−9.16
Ribavirin	−42.006	−47.391	−6.549	−2.873	−1.121	−2.274	−23.49

Drugs interacted with both enzymes are shown in bold. Values are in kcal/mol.