TABLE 2.

List of Wnt-signaling pathways downregulated in CHIR99021-treated HAVICs.

GO term ID	Biological process	Observed protein count	FDR	Proteins
GO:0030111	Regulation of Wnt signaling pathway	22	0.0016	APP, ATP6V0C, BICC1, CAV1, CCND1, COL1A1, DAB2, DDX3X, EGFR, EMD, GPC3, IGFBP2, ILK, ITGA3, JUP, LRP1, MACF1, PPAP2B, SEMA5A, SFRP4, SLC9A3R1, VCP
GO:0030177	Positive regulation of Wnt signaling pathway	13	0.0024	ATP6V0C, CAV1, COL1A1, DAB2, DDX3X, EGFR, GPC3, ILK, JUP, MACF1, SEMA5A, SFRP4, VCP
GO:0060828	Regulation of canonical Wnt signaling pathway	16	0.0111	APP, BICC1, CAV1, COL1A1, DAB2, DDX3X, EGFR, EMD, GPC3, IGFBP2, ILK, JUP, SEMA5A, SFRP4, SLC9A3R1, VCP
GO:0090263	Positive regulation of canonical Wnt signaling pathway	9	0.0212	CAV1, COL1A1, DDX3X, EGFR, ILK, JUP, SEMA5A, SFRP4, VCP

HAVIC, human aortic valve interstitial cells. FDR, false discovery rate.