TABLE 3.
Top 10 enriched biological processes in CHIR99021-treated HAVICs.
| GO term ID | Biological process | Observed protein count | FDR | Proteins |
| GO:0044281 | Small molecule metabolic process | 35 | 4.80E-08 | ACSL1, AK2, AKR1B1, ATP5I, CARKD, CCBL2, CTPS1, DARS, DECR2, DHRS7B, DUT, ENO2, ETFB, FABP5, GAPDH, GFPT2, HEXB, HK2, HMGCL, IMPA1, MAN2B1, NAMPT, NDUFA2, NDUFA5, PDHA2, PDHX, PFKP, PGK1, PHGDH, PLOD2, PMPCB, PTGS2, SHMT2, TARS, UQCRB |
| GO:0006091 | Generation of precursor metabolites and energy | 17 | 1.06E-07 | AKR1B1, ATP5I, ENO2, ETFB, GAPDH, GFPT2, HK2, HMGCL, NDUFA2, NDUFA5, NDUFAF2, PDHA2, PFKP, PGK1, PHGDH, PMPCB, UQCRB |
| GO:0009117 | Nucleotide metabolic process | 20 | 1.06E-07 | ACSL1, AK2, ATP5I, CARKD, CTPS1, DUT, ENO2, GAPDH, HK2, HMGCL, NAMPT, NDUFA2, NDUFA5, PDHA2, PDHX, PFKP, PGK1, PMPCB, PTGS2, UQCRB |
| GO:0009165 | Nucleotide biosynthetic process | 15 | 1.06E-07 | ACSL1, AK2, ATP5I, CARKD, CTPS1, DUT, ENO2, GAPDH, HK2, NAMPT, PDHA2, PDHX, PFKP, PGK1, PTGS2 |
| GO:0019637 | Organophosphate metabolic process | 25 | 1.06E-07 | ACSL1, AK2, ATP5I, CARKD, CTPS1, DUT, ENO2, FABP5, GAPDH, GFPT2, HEXB, HK2, HMGCL, IMPA1, MTMR6, NAMPT, NDUFA2, NDUFA5, PDHA2, PDHX, PFKP, PGK1, PMPCB, PTGS2, UQCRB |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | 21 | 1.06E-07 | ACSL1, AK2, ATP5I, CARKD, CTPS1, DUT, ENO2, GAPDH, GFPT2, HK2, HMGCL, NAMPT, NDUFA2, NDUFA5, PDHA2, PDHX, PFKP, PGK1, PMPCB, PTGS2, UQCRB |
| GO:0090407 | Organophosphate biosynthetic process | 19 | 1.76E-07 | ACSL1, AK2, ATP5I, CARKD, CTPS1, DUT, ENO2, FABP5, GAPDH, HEXB, HK2, IMPA1, MTMR6, NAMPT, PDHA2, PDHX, PFKP, PGK1, PTGS2 |
| GO:0009435 | NAD biosynthetic process | 8 | 2.87E-07 | CARKD, ENO2, GAPDH, HK2, NAMPT, PFKP, PGK1, PTGS2 |
| GO:1901566 | Organonitrogen compound biosynthetic process | 28 | 3.45E-07 | ABCB6, ACSL1, AK2, ATP5I, CARKD, CHCHD1, CTPS1, DARS, DUT, EEF1A2, EEFSEC, EIF4EBP1, ENO2, FABP5, GAPDH, GFPT2, HK2, MRPL12, NAMPT, PDHA2, PDHX, PFKP, PGK1, PHGDH, PLOD2, PTGS2, SHMT2, TARS |
| GO:0007005 | Mitochondrion organization | 16 | 5.29E-07 | AFG3L2, APOOL, ATP5I, HK2, HMGCL, LONP1, MIPEP, NDUFA2, NDUFA5, NDUFAF2, PMPCB, SAMM50, TIMM13, TIMM22, TOMM70A, UQCRB |
HAVIC, human aortic valve interstitial cells. FDR, false discovery rate.