Table 1.
Clinical characteristics according to median values of 1,25(OH)2D.
| Baseline demographic and clinical characteristics | <41.5 pg/ml (n = 111) | ≥41.5 pg/ml (n = 117) | P value |
|---|---|---|---|
| Age (mean ± SD) | 68.9 ± 12,8 | 64.4 ± 11,3 | 0.005 |
| Weight (Kg±SD) | 78 ± 17 | 74 ± 14.3 | 0.14 |
| Male Sex (%) | 76,6% | 69.2 | 0.24 |
| BMI (mean ± SD) | 27.0 ± 4,9 | 26.6 ± 4.2 | 0.54 |
| Hypercholesterolemia (%) | 48.3 | 59.3 | 0.11 |
| Diabetes mellitus (%) | 46.2 | 27.7 | 0.013 |
| Renal failure (%) | 29.3 | 9.3 | <0.001 |
| Active smokers (%) | 28.4 | 26.3 | 0.62 |
| Hypertension (%) | 73.3 | 61.0 | 0.05 |
| History of MI (%) | 21.6 | 19.8 | 0.87 |
| Previous PCI (%) | 25.0 | 22.2 | 0.65 |
| Previous CABG (%) | 8.6 | 9.3 | 1.00 |
| ACS type (%) | 0.14 | ||
| NSTEMI/UA (%) | 65.3 | 77.8 | |
| STEMI (%) | 34.7 | 22.2 | |
| CAD (%) | |||
| Left Main disease or 3-vessel CAD (%) | 52.5 | 44.6 | 0.46 |
| Concomitant medications | |||
| ACE inhibitors (%) | 22.1 | 23.7 | 0.8 |
| ARB (%) | 28.1 | 17.9 | 0.085 |
| Beta blockers (%) | 44.7 | 40.7 | 0.6 |
| Nitrates (%) | 18.3 | 13.7 | 0.37 |
| Statins (%) | 36.5 | 40.2 | 0.59 |
| ASA (%) | 45.2 | 42.7 | 0.79 |
| Clopidogrel (%) | 10.6 | 6.0 | 0.24 |
| Calcium antagonists (%) | 28.1 | 17.8 | 0.085 |
| Diuretics (%) | 33.3 | 18.1 | 0.007 |
| Vitamin D (%) | 3.6 | 6.0 | 0.54 |
| Antidiabetic therapy | 0.02 | ||
| Oral hypoglycemic drugs (%) | 13.6 | 5.2 | |
| Insulin (%) | 14.4 | 4.3 | |
| Biochemistry parameters | |||
| Platelets (10ˆ6/ml; mean ± SD) | 222.82 ± 69.7 | 244.24 ± 68.9 | 0.019 |
| Haemoglobin (g/dl) | 13.3 ± 2.1 | 13.8 ± 3.1 | 0.16 |
| WBC (10ˆ3/ml; mean ± SD) | 10.2 ± 4.2 | 9.2 ± 2.8 | 0.032 |
| HDL cholesterol (mg/dL) | 43.9 ± 19.5 | 47.4 ± 20.7 | 0.2 |
| LDL cholesterol (mg/dl) | 98.3 ± 34 | 112.3 ± 40 | 0.03 |
| Glycaemia (mg/dL) | 135.3 ± 61 | 114.2 ± 29.8 | 0.01 |
| HbA1c (%) | 6.2 ± 1.1 | 5.9 ± 0.9 | 0.068 |
| 25(OH)D (ng/ml) | 16.5 ± 10.3 | 19.1 ± 8.8 | 0.046 |
| Creatinine (mg/dL) | 1.04 ± 0.6 | 0.86 ± 0.497 | 0.011 |
| C reactive protein (mg/dL) | 1.2 ± 2.2 | 0.7 ± 1.4 | 0.09 |
| Uric acid (mg/dl) | 6.1 ± 1.6 | 5.7 ± 1.6 | 0.056 |
CAD = Coronary Artery Disease; MI = Myocardial Infarction; PCI = Percutaneous Coronary Interventions; CABG = Coronary Artery Bypass Grafting; STEMI = ST-Elevation Myocardial Infarction; ACS = Acute Coronary Syndrome; ACE = Angiotensin Converting Enzyme; ARB = Angiotensin Receptor Blockers.