Fig. 6.

Increased expression of inflammatory cytokines in the CNS of hRSV-infected mice. mRNA and protein levels of cytokines (analyzed by RT-qPCR and ELISA) in the brain of mice intranasally infected with 1x10⁶ PFU of hRSV or UV-hRSV and mock-treated mice. The following graphs show mRNA levels for: (a) IL-6; (b) TNF-α; (c) IL-4; (d) CCL2; and (e) CD200. The following graphs show the content of protein levels for: (f) IL-6; (g) TNF-α; (h) IL-4; (i) CCL2; and (j) CD200. Three independent experiments were performed (N = 3–4 mice per experimental group per each experiment). Comparisons between the groups were done using one-way ANOVA test with Tukeýs posttest. ** P < 0.005, *P < 0.05 indicates means are significantly. Bars indicate mean ± SEM.