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. 2020 Sep 24;16(9):e1008817. doi: 10.1371/journal.ppat.1008817

Fig 5. Sensitivity and specificity comparison of serological assays.

Fig 5

(A) Specificity was determined for each serological assay using a panel of 50 pre-pandemic serum samples the St Thomas’ emergency admissions cohort (STH Healthy, March 2019). Overall sensitivity was determined for each serological assay, based on results for 110 serum samples from known SARS-CoV-2-positive individuals (shown in Figs 3 and 4). For the lateral flow assays, a positive result for IgM, IgG or both is considered positive. For the EUROIMMUN and in-house ELISAs, sensitivities for IgA, IgM and IgG are calculated separately. (B) Sensitivity and 95% confidence intervals (vertical lines) were determined for each serological assay at increasing days POS. 95% sensitivity is indicated by the horizontal dashed line. Results for each test were categorised according to whether the serum sample was from <10, ≥10, ≥14, or ≥20 days POS.