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. 2020 Sep 14;16(9):e1008185. doi: 10.1371/journal.pcbi.1008185

Fig 3. Buffers and potentiators correspond to multifunctional enzymes.

Fig 3

We computed the pleiotropy and number of weak negative genetic interactions as proxies of enzyme multifunctionality (see main text and Methods). Modifiers (both buffers and potentiator) show stronger pleiotropy (mean pleiotropy modifiers = 0.65, mean pleiotropy nonmodifiers = 0.05, two-sample Kolmogorov-Smirnov test p = 1.6e-6) and number of weak negative genetic interactions (g.i.) (mean number of weak g.i. modifiers = 23.38, weak g.i. nonmodifiers = 0.6, KS p = 6.9e-8).