Table 3. cDNA with exon 53 skipping and INDEL rates in cDNA with exon 53.

	% of cDNA with exon 53 skipping	cDNA without exon 53 skipping
		Total INDELs (%)	Restoring INDELs (%)a
Muscle tissue	21.7±6.4 (n = 3)	0.37±0.12 (n = 3)	ND
Non-targeting RNP	54.3 (n = 1)	1.4 (n = 1)	1.4 (n = 1)b
Sa-gRNA2 RNPs	58.5±3.6 (n = 3)	5.3±0.95 (n = 3)	3.5±0.45 (n = 3)
Sp-gRNA1 RNPs	56.4± 2.9 (n = 2)	11.2±1.5 (n = 3)	6.1±1.0 (n = 3)
Sp-gRNA2 RNPs	45.3±4.8 (n = 2)	25.9±2.2 (n = 3)**	16.1±2.2 (n = 3)**

^aCalculated based on the top 20 most frequently observed readings, accounting for 85%~95% of all readings.

^bThe two types of INDELs accounted for all observed INDELs, all restored dystrophin reading frame.

** indicates p<0.01 when compared with values of Sp-gRNA1 or Sa-gRNA1 (Tukey’s Multiple Comparison Test following ANOVA).