Table 2.

Potential glucose thresholds for surveillance of type 1 diabetes diagnosis by negative predictive value at 6 months and number of 2-hour oral glucose tolerance tests that would need to be completed

	OGTT glucose threshold, mg/dL	n	Sensitivity, %	Specificity, %	Negative predictive value at 6 mo, %	Participants requiring 2-h OGTT, %
DPT-1 (n = 654)	2-h ≥ 140	206	74.80	69.29	98.9	15.1
	1-h ≥ 155	188	74.80	72.03	99.3	31.5
	1-h ≥ 160	130	41.40	80.55	99.3	28.7
	1-h ≥ 170	97	33.13	85.53	98.6	19.9
	1-h ≥ 180	63	24.86	90.84	98.5	14.8
	1-h ≥ 190	789	71.19	81.92	98.5	9.6
TNPTP (n = 4610)	2-h ≥ 140	1548	79.12	66.51	99.4	17.1
	1-h ≥ 155	1338	75.85	70.96	99.5	33.6
	1-h ≥ 160	1011	74.21	78.36	99.4	29.0
	1-h ≥ 170	717	67.83	84.62	99.4	21.9
	1-h ≥ 180	500	52.15	89.52	99.4	15.6
	1-h ≥ 190	99	49.83	85.69	99.1	10.8

Abbreviations: DPT-1, Diabetes Prevention Trial–Type 1; OGTT, oral glucose tolerance test; TNPTP, TrialNet Pathway to Prevention.