Skip to main content
. 2020 Sep 14;16(9):e1008813. doi: 10.1371/journal.ppat.1008813

Fig 3. Structural distribution of Nef residues associated with SERINC antagonism.

Fig 3

(A, B, C) The location of Nef polymorphisms associated with internalization of SERINC5 (A, green), SERINC3 (B, blue), or both proteins (C, magenta) are indicated on a composite structural model of HIV Nef (based on PDB 2NEF and 1QA5) (Lamers, PLoS One 2011). Residue 94 (SERINC5, panel A) and residues 8 and 11 (SERINC3, panel B) are highlighted in red. (D, E, F) The distribution of natural polymorphisms associated with internalization of SERINC5 (n = 48) (D), SERINC3 (n = 45) (E) or both proteins (n = 22) (F) among Nef’s major functional domains is illustrated.