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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Curr Opin Syst Biol. 2020 Jul 7;20:17–25. doi: 10.1016/j.coisb.2020.07.001

Figure 1: Schematic of the nonlinear evolution of disease.

Figure 1:

The black line represents the linear model of disease whereby disease progression happens uniformly and in a constant manner to the disease state. The red curve represents the nonlinear evolution of disease whereby a stable pre-disease state undergoes a rapid transition (transition state) to a disease state. Intervention at the transition state may result in better outcomes.