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. 2020 Jun 28;21(9):799–805. doi: 10.1080/15384047.2020.1779005

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — GUCY2C ligand mRNA expression is retained after monoallelic loss of APC. (a) GUCY2C, uroguanylin, and guanylin mRNA expression quantified by RNAseq in colorectal carcinomas, classified by stage of disease [stage I (n = 57), stage II (n = 136), stage III (n = 113), stage IV (n = 52)], and normal colorectum (n = 51) from the TCGA database.³⁸ (b) GUCY2C and uroguanylin mRNA quantified by qRT-PCR from jejunum in wildtype (n = 12), Apc^min/+ (n = 11), Guca2b^−/- (n = 3) and Apc^CKO (n = 5) mice. (c) GUCY2C and guanylin mRNA quantified by qRT-PCR from proximal colon in wildtype (n = 12), Apc^min/+ (n = 11), Guca2a^−/- (n = 3) and Apc^CKO (n = 5) mice. n.s., not significant, * p < .05, ** p < .01, *** p < .001, **** p < .0001.