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. 2020 Aug 23;21(9):841–852. doi: 10.1080/15384047.2020.1798696

Table 1.

In vitro Characterization of Sphk1 and SphK2 Inhibitor selectivity.

Compound # Name Structure Ki (μM) Ref
      SphK1 inhibition SphK2 inhibition  
1 N,N-dimethyl-sphingosine graphic file with name KCBT_A_1798696_ILG0001.gif 16 14 37
2 SKI-II graphic file with name KCBT_A_1798696_ILG0002.gif 16 8 15,37
3 PF-543 graphic file with name KCBT_A_1798696_ILG0003.gif 0.004 0.5 19
4 SKI-I graphic file with name KCBT_A_1798696_ILG0004.gif IC50 = 1.2 IC50 = 10 15,30
5 SK1-I graphic file with name KCBT_A_1798696_ILG0005.gif 10 ND 17
6 SKI-V graphic file with name KCBT_A_1798696_ILG0006.gif IC50 = 2 ND 15
7 FTY-720 (Fingolimod) graphic file with name KCBT_A_1798696_ILG0007.gif 2 Substrate 38
8 SKI-178 graphic file with name KCBT_A_1798696_ILG0008.gif 1.3 ND 30
9 ABC294640 graphic file with name KCBT_A_1798696_ILG0009.gif ND 10 20
10 K145 graphic file with name KCBT_A_1798696_ILG0010.gif ND 6 21
11 SKI-5 C graphic file with name KCBT_A_1798696_ILG0011.gif 15 46 18
12 DL-threo-dihydro-sphingosine (Safingol) graphic file with name KCBT_A_1798696_ILG0012.gif 5 5 39

ND: Not Determined in Published Studies.