Table 2.

Most frequent genomic imbalances observed in 103 clear cell RCCs.

Chromosome Region	Genomic Location	No. Cases with Imbalance	% of Cases	Candidate Genes in Region
3p26.3-p24.3	3:7,674,135–20,889,848	99	96	VHL
3p26.3p21.1	3:81,668–52,705,865	92	89	VHL, SETD2, BAP1, PBRM1
5q34q35.3	5:166,185,273–180,698,177	58	56	STC2, WWC1, SQSTM1
14q21.1q32.33	14:43,841,602–107,267,751	42	41	PTPD1, SEL1L, HIF1A, ARID4A
6q24.3q25.3	6:148,767,166–160,741,894	39	38	LATS1, IGF2R
7q22.2q34	7:104,399,110–142,006,016	35	34	BRAF, MET
9p21.3	9:21,168,273–23,655,806	33	32	CDKN2A
1p36.31p36.11	1:6,824,284–24,861,54	27	26	CASP9, ARID1A
20q13.31qter	20:36,195,833–48,266,697	19	18	SRC, MMP9