Figure 1.

Heat shock proteins mediated cell survival and anti-apoptotic pathways in lung cancer. Hsp27 interacts with various apoptotic and cell survival regulators such as cytochrome c, caspase-3, DAXX, FADD, BAX, AKT, 14-3-3ζ and inhibits apoptosis and induces cell survival. Hsp70 also deregulates several signal proteins that are involved in the induction of apoptosis, senescence thus contributing to the tumor cell survival. Hsp90 interacts and stabilizes mutant receptors and enables them to recruit tumor cell proliferative signal pathways.