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Characterization of MCD3 ASO-SHA NP nanocomplexes
| size and zeta potential | Size [nm] (average ± SD) | Zeta potential [mV] (average ± SD) | |
|---|---|---|---|
| SHA NP | 28.2±1.9 | −9.6 ± 0.2 | |
| SHA NP (+azide) | 30.8 ± 1.7 | −6.4 ± 0.7 | |
| MXD3 ASO-SHA NP nanocomplexes | 38.9 + 1.3 | 14.8 ±0.4 | |
| ASO loading | MXD3 ASO[μg] | [%] of total | Bound ASO molecules per nanoparticle |
| MXD3 ASO-SHA NP nanocomplex pellet (bound MXD3 ASO) | 3.0 | 10.1 | 60.6 |
| Supernatant (unbound MXD3 ASO) | 26.0 | 88.9 |
SD: standard deviation
