Figure 2.
Altered outward potassium currents and inward rectifier potassium currents in ventricular cardiomyocytes isolated from WT and KO mouse hearts after 20 weeks of ND or HFD feeding. a) Typical examples of voltage-dependent outward potassium current tracings. b) Graph of the current density of outward potassium currents (n = 8 cardiomyocytes from n = 3 mice each group). c) Typical examples of the inward rectifier potassium current recorded in a whole-cell configuration. d) Graph of the current density of inward rectifier potassium current (n = 8 cardiomyocytes from n = 3 mice each group). IKpeak, peak outward potassium current; Ito, f, fast transient outward potassium currents; IK, slow, slowly inactivating potassium current; Iss, non-inactivating current component; Ik1, inward rectified potassium currents. Data are expressed as mean ± SEM. * p < 0.05 vs. WT-ND group, # p < 0.05 vs. WT-HFD group.