Table 5.

The mechanism of TRPM7 involved in central nervous system diseases.

Disease	Pathogenesis	The physiological processes/signaling pathways involved in TRPM7
Alzheimer disease(AD) [30–32]	Aβ deposition; Autophagy and metabolic dysfunction; Synapse damage and synaptic dysfunction; Imbalance of divalent cation in vivo; Oxidative stress; Tau protein hyperphosphorylation; Central cholinergic neuron injury and so on.	Improved the Mg2+ level, and adjusted the permeability of BBB-penetrating peptide and cause Aβ deposition decrease; Induced Ca2+ influx to enhance basal autophagy; Participated in the occurrence of oxidative stress.
Parkinson’s disease (PD) [20,33–35]	Substantia nigra dopamine neuron degeneration; Oxidative stress; Genetics;Environmentand so on	Activated pro-apoptotic signaling pathways and particaipated in neurodegeneration of dopaminergic neurons and terminals.
Amyotrophic Lateral Sclerosis (ALS) [29,36,37]	Motor neuron injury; Genetics;Environmentand so on.	Develop a molecular complex with vesicles and participate in regulating the release of neurotransmitters.
Stroke [38–41]	Glutamate receptor-mediated Ca2+ overload and neurotoxicity.	Key of neuronal injury in ischemic conditions: mediated Ca2+ toxicity, mediate Zn2+ toxicity.
Multiple sclerosis (MS) [42]	Inflammatory demyelination of white matter in the central nervous system.	Regulated the formation of glial scars and led to impaired nerve function.