Figure 13.

The nucleotide sequences of the hypervariable core domains of the six active aptamers identified in references 123 and 124. The most active aptamer was FELIAP. The positive signs on the right is indicative of activity against FXIa as determined in S-2366 chromogenic substrate hydrolysis assay. +++ = most active, ++ = moderately active, + = slightly active. Highlighted nucleotides indicate differences among the first four aptamers. ‘*’ in the fourth aptamer indicates that the last nucleotide is missing.